Pharmacological analysis in experimental lung fibrosis performed by MRI

Introduction: Edema and collagen deposition are processes involved in the inflammatory response, which are fundamental to wound-healing [1]. Despite their diverse symptoms and etiologies, asthma and chronic obstructive pulmonary disease, as well as many other forms of pulmonary pathologies, share the common features of airways remodeling and excess collagen deposition [2]. The mechanisms behind such changes are not entirely clear. Furthermore, the relationship between inflammation and fibrosis is complicated by the fact that although fibrosis may develop concomitantly or subsequently to inflammation, the real causal relationship between the two remains unknown [2,3].